INH6
INH6
CAS: 1001753-24-7
Molecular Formula: C19H18N2OS
INH6 - Names and Identifiers
| Name | INH6 |
| Synonyms | INH6 INH-6 INH6 N-(4-Mesitylthiazol-2-yl)benzaMide N-[4-(2,4,6-trimethylphenyl)thiazol-2-yl]benzamide N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide |
| CAS | 1001753-24-7 |
INH6 - Physico-chemical Properties
| Molecular Formula | C19H18N2OS |
| Molar Mass | 322.42 |
| Storage Condition | 2-8℃ |
| In vitro study | INH6 effectively acts on Hec1/Nek2 complex to degrade it, and shows effective cell killing activity in MDA-MB231,MDA-MB468,HeLa and K562 cell lines, with IC50 of 1.7 and 2.1 respectively, 2.4 and 2.5 μm. INH6 also causes mitotic abnormalities in HeLa cells and induces apoptosis. |
INH6 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.102 ml | 15.508 ml | 31.015 ml |
| 5 mM | 0.62 ml | 3.102 ml | 6.203 ml |
| 10 mM | 0.31 ml | 1.551 ml | 3.102 ml |
| 5 mM | 0.062 ml | 0.31 ml | 0.62 ml |
Last Update：2024-01-02 23:10:35
INH6 - Reference Information
| biological activity | INH6 is a potent Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction, and lead to abnormal chromosome arrangement. |
| Target | IC50: 2.4 μm (HeLa), 1.7 μm (MB231), 2.1 μm (MB468), 2.5 μm (K562) |
Last Update：2024-04-10 22:29:15
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CAS: 1001753-24-7
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CAS: 1001753-24-7
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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